Design, synthesis and biological evaluation of a novel series of potent, orally active adenosine A1 receptor antagonists with high blood-brain barrier permeability.

S Kuroda, F Takamura, Y Tenda, H Itani…

文献索引：Chemical and Pharmaceutical Bulletin, , vol. 49, # 8 p. 988 - 998

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被引用次数: 30

摘要

... Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 1–6, Kashima 2-chome, Yodogawa-ku, Osaka-shi ... Chemistry Synthetic routes for the novel 3-(2-substi- tuted-3-oxo-2,3 ... 6-yl)- 2-phenylpyrazolo[1,5-a]pyridine is an excellent pharma- cophore for the ...