Synthesis, antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides

D Kumar, A Kapoor, A Thangadurai, P Kumar…

文献索引：Kumar, Davinder; Kapoor, Archana; Thangadurai, Ananda; Kumar, Pradeep; Narasimhan, Balasubramanian Chinese Chemical Letters, 2011 , vol. 22, # 11 p. 1293 - 1296

全文：HTML全文

被引用次数: 9

摘要

A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides (1–20) was synthesized and tested for in vitro antimicrobial activity. The results of antimicrobial studies indicated that the compounds having dinitro, methoxy, hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones. The QSAR investigation indicated the importance of the topological parameter, third order molecular connectivity index (3χ) ...