Journal of Organometallic Chemistry

Synthesis of rac-2′-(trimethylsilyl) isovaline: A novel silicon-containing α, α-dialkylated α-amino acid

S Falgner, G Buchner, R Tacke

文献索引：Falgner, Steffen; Buchner, Ginka; Tacke, Reinhold Journal of Organometallic Chemistry, 2010 , vol. 695, # 24 p. 2614 - 2617

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被引用次数: 7

摘要

An efficient, convenient, and reliable multi-step synthesis of rac-2′-(trimethylsilyl) isovaline (rac-3) that uses inexpensive reagents in all steps has been developed, starting from diethyl malonate (overall yield 28%). Compound rac-3 is the first α-ethylated α, α-dialkylated silicon- containing α-amino acid.