Bioorganic & medicinal chemistry letters

Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps

P Wei, GW Kaatz, RJ Kerns

文献索引：Wei, Peng; Kaatz, Glenn W.; Kerns, Robert J. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3093 - 3097

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被引用次数: 19

摘要

In this study the chemical modification of paroxetine was employed to determine which structural differences between the paroxetine-like and femoxetine-like selective serotonin reuptake inhibitors is responsible for the differential potency of these agents in the inhibition of Staphylococcus aureus multidrug efflux pump systems.