Tetrahedron Letters

Efficient syntheses of 2-fluoroalkylbenzimidazoles and-benzothiazoles

O René, A Souverneva, SR Magnuson, BP Fauber

文献索引：Rene, Olivier; Souverneva, Alexandra; Magnuson, Steven R.; Fauber, Benjamin P. Tetrahedron Letters, 2013 , vol. 54, # 3 p. 201 - 204

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被引用次数: 5

摘要

We report an efficient one-step route to 2-fluoroalkylbenzimidazoles and-benzothiazoles via the condensation of fluorinated carboxylic acids and aromatic diamines or aminothiophenols. Additionally, we describe the syntheses of fluoroalkyl- azabenzimidazoles,-purines, and-imidazolopyrazines. This method is high-yielding with broad scope and is operationally simple with potential application to parallel synthesis.