Tetrahedron: Asymmetry

Using ionic liquid [EMIM][CH 3 COO] as an enzyme-'friendly'co-solvent for resolution of amino acids

H Zhao, L Jackson, Z Song, O Olubajo

文献索引：Zhao, Hua; Jackson, Lee; Song, Zhiyan; Olubajo, Olarongbe Tetrahedron Asymmetry, 2006 , vol. 17, # 17 p. 2491 - 2498

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被引用次数: 87

摘要

An ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate [EMIM][CH3COO], was used in 0– 4.0 M (∼ 60% IL, v/v), as a nonvolatile organic medium for the enzymatic resolution of amino acids. When dl-phenylalanine methyl ester was studied as a model substrate, high enantiomeric excesses (ee) of l-amino acid were obtained in all ionic concentrations; however, lower yields were observed at high IL concentrations. This IL is more enzyme-' ...