Studies on biologically active pteridines. IV. Synthesis of several biopterin derivatives as an antigen in radioimmunoassay for biopterin.

T Sugimoto, S Matsuura, T Nagatsu

文献索引：Sugimoto; Matsuura; Nagatsu Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 8 p. 2344 - 2347

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被引用次数: 13

摘要

The synthesis of biopterin, D (and L)-erythro-neopterins, and their derivatives having a substituent at the 2-amino group via the 2-methylthio analogues is described. The 2- (methylthio) pteridines were synthesized by condensation of 4, 5-diamino-6-hydroxy-2- (methylthio) pyrimidine with 5-deoxy-L-arabinose and D (and L)-arabinose phenylhydrazones, followed by oxidation with K 3 [Fe (CN) 6] and O 2 in the presence of ...