Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities

YY Zhang, JL Mi, CH Zhou, XD Zhou

文献索引：Zhang, Yi-Yi; Mi, Jia-Li; Zhou, Cheng-He; Zhou, Xiang-Dong European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4391 - 4402

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被引用次数: 37

摘要

A series of novel fluconazoliums were synthesized and their bioactive evaluation as potential antibacterial and antifungal agents were described. Some target compounds displayed good and broad-spectrum antimicrobial activities with low MIC values ranging from 0.25 to 64 μg/mL against all the tested strains, including three Gram-positive bacteria (Staphylococcus aureus, MRSA and Bacillus subtilis), three Gram-negative bacteria ( ...