Design, Synthesis, and Evaluation of Phospholipid Analogs as Inhibitors of the Bacterial Phospholipase C from Bacillus cereus

SF Martin, YL Wong, AS Wagman

文献索引：Martin, Stephen F.; Wong, Yue-Ling; Wagman, Allan S. Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 4821 - 4831

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被引用次数: 58

摘要

Introduction The phospholipase C (PLC) class of enzymes has attracted intense interest in the biological and chemical communities because of the central role these enzymes play in the regulatory functions related to agonist- receptor interaction and transmembrane ~ignaling.l-~ In the first stage of this process, agonists including hor- mones, neurotransmitters, and some growth factors bind to a Gprotein linked receptor in the membrane to initiate a cascade that leads to the ...