Synlett

A stable, convertible isonitrile as a formic acid carbanion [-COOH] equivalent and its application in multicomponent reactions

O Kreye, B Westermann, LA Wessjohann

文献索引：Kreye, Oliver; Westermann, Bernhard; Wessjohann, Ludger A. Synlett, 2007 , # 20 p. 3188 - 3192

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被引用次数: 21

摘要

Abstract The application of 2-(2, 2-dimethoxyethyl) phenyl isonitrile in Ugi, Passerini, and Ugi-Smiles reactions is described. The simple transformation to highly activated indolyl amides allows functional-group conversion of the isonitrile moiety into a variety of carboxylic acid derivatives, overall acting as a neutral, nucleophilic COOH equivalent.