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Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives

A Khalafi-Nezhad, MNS Rad, H Mohabatkar…

文献索引:Khalafi-Nezhad; Soltani Rad; Mohabatkar; Asrari; Hemmateenejad Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1931 - 1938

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被引用次数: 163

摘要

In view of obtaining some potential antibacterial compounds, we have described synthesis of some chloroaryloxyalkyl imidazole and benzimidazole derivatives. The relevant step in the synthetic sequence was the initial condensation of 4-chloro or 2, 4-dichlorophenol with 1, n-dibromoalkanes (n= 2, 4, 5) to provide compounds 3a–f in sufficient yields. The subsequent condensation of 3a–f with some imidazole derivatives and benzimidazole ...