Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor

AT Gillmore, M Badland, CL Crook…

文献索引：Organic Process Research and Development, , vol. 16, # 12 p. 1897 - 1904

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被引用次数: 8

摘要

... Organic Process Research & Development. ... salt ((S)-CSA) was selected for tablet formulation which meant that a new API crystallization procedure was required ... allow us to address the scale-up issues observed during the reduction of nitroalkene 6. Routine process safety testing ...