Nucleosides, Nucleotides and Nucleic Acids

An improved one-pot synthesis of nucleoside 5′-triphosphate analogues

I Gillerman, B Fischer

文献索引：Gillerman, Irina; Fischer, Bilha Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 3 p. 245 - 256

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被引用次数: 30

摘要

Nucleoside 5′-triphosphate (NTP) analogues are valuable tools for biochemical and medicinal research. Therefore, a facile and efficient synthesis of NTP analogues is required. Here, we report on an improved nucleoside 5′-triphosphorylation procedure to obtain pure products after liquid chromotagrpahy (LC) separation with no need for high performance liquid chromatography (HPLC) purification. To improve the selectivity of the reaction we ...