Catalytic antibodies

J Jacobs, PG Schultz, R Sugasawara…

文献索引：Jacobs, Jeffrey; Schultz, Peter G.; Sugasawara, Renee; Powell, Michael Journal of the American Chemical Society, 1987 , vol. 109, # 7 p. 2174 - 2176

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被引用次数: 180

摘要

Preferential binding and stabilization of the transition state arising from attack of water on antibody-complexed substrate 1 should result in a decrease of the free energy of activation for the reaction. Several factors were considered in the experimental design:(1) phosphonates have been reported to act as transition-state inhibitors for proteolytic enzyme $(2) considerable mechanistic information is available on the nonenzymatic hydrolysis of ...