Synthesis of N??Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications

J Boulos, J Jakubik, A Randakova…

文献索引：Boulos, John; Jakubik, Jan; Randakova, Alena; Avila, Cristina Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1363 - 1367

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摘要

Abstract Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonist [3 H] quinuclidinyl benzilate in radioligand muscarinic binding assays (3 H-QNB) in bioassays. One of the heterocyclic salts, compound 7, met the significance criteria in these assays (> 50% inhibition) at 10 μM of the nonselective muscarinic antagonist (3 H-QNB) in cells of the Wistar rat cerebral ...