Antiviral and tumor cell antiproliferative SAR studies on tetracyclic eudistomins—II
JH van Maarseveen, HW Scheeren, E De Clercq…
文献索引：Van Maarseveen, Jan H.; Scheeren, Hans W.; De Clercq, Erik; Balzarini, Jan; Kruse, Chris G. Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 5 p. 955 - 970
In a search for the minimum pharmacophore of the naturally occurring tetracyclic eudistomins, five structural analogues (4–8) were evaluated for their in vitro antiviral and tumor cell antiproliferative activities. For the synthesis of these derivatives both intra-and intermolecular Pictet-Spengler reactions have been used. Opening of the β-carboline annulated 7-membered D-ring in 6 and 7 resulted in a complete loss of activity. On the ...
