Comparison of fatty acid and polyketide biosynthesis: stereochemistry of cladosporin and oleic acid formation in Cladosporium cladosporioides
BJ Rawlings, PB Reese, SE Ramer…
文献索引：Rawlings, Bernard J.; Reese, Paul B.; Ramer, Shawn E.; Vederas, John C. Journal of the American Chemical Society, 1989 , vol. 111, # 9 p. 3382 - 3390
Abstract: Stereochemical aspects of the biosynthesis of the polyketide cladosporin (1) and of oleic acid (2) by Cladosporium cladosporioides NRRL 5507 were compared by use of stable isotope labeling and 2D NMR spectrometry. The absolute stereochemistry of 1 was confirmed by degradation to (2R, 6S)-(-)-(6-methyltetrahydropyran-2-yl) acetic acid (12). Incorporations of sodium [I-l3C]-,[2-I3C]-,[1, 2-I3C2]-,[l-'3C,'802]-,[1-'3C, 2H3]-, and [2-13C, ...
