Synthesis and mass spectrometric identification of the major amino acid adducts formed between sulphur mustard and haemoglobin in human blood
…, AG Hulst, HC Trap, LPA de Jong, HP Benschop
文献索引：Noort, Daan; Hulst, Albert G.; Trap, Hendrik C.; De Jong, Leo P. A.; Benschop, Hendrik P. Archives of Toxicology, 1997 , vol. 71, # 3 p. 171 - 178
Abstract As part of a program to develop methods for the verification of alleged exposure to sulphur mustard, we synthesized and characterized three amino acid adducts presumably formed by alkylation of haemoglobin: 4-(2-hydroxyethylthioethyl)-l-aspartate, 5-(2- hydroxyethylthioethyl)-l-glutamate and N1-and N3-(2-hydroxyethylthioethyl)-l-histidine. Suitable derivatization methods for GC/MS analysis were developed for these adducts as ...
