A facile and direct synthesis of alendronate from pyrrolidone

G Xu, Y Xie, X Wu

文献索引：Xu, Guangyu; Xie, Yuyuan; Wu, Xihan Organic Preparations and Procedures International, 2004 , vol. 36, # 2 p. 185 - 187

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被引用次数: 2

摘要

Alendronate (Fosamax), 4-amino-1-hydroxybutylidenebisphosphonic acid (alendronic acid) monosodium, is an anti-resorption agent used for the prevention and treatment of osteoporosis and for the prevention of osteoporotic fractures in postmenopausal women.'Various methods for the preparation of alendronic acid have been disclosed. In most of these methods, it was obtained from the reaction of y-aminobutyric acid with ...