J. Chem. Soc., Perkin Trans. 1

… alkylation of phenol with cyclopentanol over montmorillonite K10: An efficient synthesis of 1-(2-cyclopentylphenoxy)-3-[(1, 1-dimethylethyl) amino] propan-2-ol {(S)- …

P Phukan, A Sudalai

文献索引：Phukan, Prodeep; Sudalai, Arumugam Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 3015 - 3018

全文：HTML全文

被引用次数: 8

摘要

Regioselective alkylation of phenol with cyclopentanol is achieved over Montmorillonite K10 clay, producing 2-cyclopentylphenol, the key intermediate. The synthesis of optically active ([])-penbutolol 1, an important antihypertensive drug, is realized in 5 steps from 2- cyclopentylphenol by employing Sharpless asymme