1??, 2??, and 4??Ethynylpyrenes in the Structure of Twisted Intercalating Nucleic Acids: Structure, Thermal Stability, and Fluorescence Relationship

VV Filichev, IV Astakhova, AD Malakhov…

文献索引：Filichev, Vyacheslav V.; Astakhova, Irina V.; Malakhov, Andrei D.; Korshun, Vladimir A.; Pedersen, Erik B. Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9968 - 9980

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被引用次数: 40

摘要

Abstract A postsynthetic, on-column Sonogashira reaction was applied on DNA molecules modified by 2-or 4-iodophenylmethylglycerol in the middle of the sequence, to give the corresponding ortho-and para-twisted intercalating nucleic acids (TINA) with 1-, 2-, and 4- ethynylpyrene residues. The convenient synthesis of 2-and 4-ethynylpyrenes started from the hydrogenolysis of pyrene that has had the sulfur removed and separation of 4, 5, 9, 10 ...