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Synthesis of N-[4-(propyl) cyclohexyl]-amides with anti-inflammatory and analgesic activities

…, B Asproni, M Palomba, L Auzzas, R Cerri, F Palagiano…

文献索引：Pau, Amedeo; Boatto, Gianpiero; Asproni, Battistina; Palomba, Michele; Auzzas, Luciana; Cerri, Riccardo; Palagiano, Francesco; Filippelli, Walter; Falcone, Giuseppe; Motola, Giulia Farmaco, 2000 , vol. 55, # 6-7 p. 439 - 447

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被引用次数: 6

摘要

Seventeen (un) substituted N-[4-(propyl) cyclohexyl]-amides (6a–h, 7a–h and 8) were synthesized and tested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron- donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure– ...