Total synthesis of L-659,699, a novel inhibitor of cholesterol biosynthesis

…, JV Heck, JC Chabala, MN Chang

文献索引：Chiang; Yang; Heck; Chabala; Chang Journal of Organic Chemistry, 1989 ,  vol. 54,  # 24  p. 5708 - 5712

全文：HTML全文

被引用次数: 26

摘要

18 2-butenoate with activated zinc dust in refluxing THF gave 19 (a mixture of four isomers) in 44% yield along with 32% of the &lactone 20. Dehydration of 19 with thionyl chloride in the presence of pyridine in refluxing CH2C12 afforded 21 (30%) and other isomers. The protected compound 21 was converted to the target compound, L-659,699, by de-