Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives

D Bouzard, P Di Cesare, M Essiz…

文献索引：Bouzard, D.; Di Cesare, P.; Essiz, M.; Jacquet, J. P.; Kiechel, J. R.; et al. Journal of Medicinal Chemistry, 1990 ,  vol. 33,  # 5  p. 1344 - 1352

全文：HTML全文

被引用次数: 72

摘要

Route B was preferred to route C to avoid a substitution at C-6.8 The 3-amino or 3- (aminoalkyl) group of the pyrrolidines did not require protection as displacement occurred exclusively at the ring nitrogen as previously reported. 16 Thus, 20b can be prepared in excellent yield by using 3-aminopyrrolidine instead of 3-[(trifluoroacety1) aminolpyrrolidine. Structures and physical properties are displayed in Table I. Piperazines and pyrrolidines ...