前往化源商城

举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Structural requirements for catalysis by chorismate mutase

…, RE Padykula, JD Kronis, RA Aleksejczyk…

文献索引：Pawlak, John L.; Padykula, Robert E.; Kronis, John D.; Aleksejczyk, Robert A.; Berchtold, Glenn A. Journal of the American Chemical Society, 1989 , vol. 111, # 9 p. 3374 - 3381

全文：HTML全文

被引用次数: 43

摘要

Abstract: The structural requirements for mutase-catalyzed Claisen rearrangement by chorismate mutase-prephenate dehydrogenase from Escherichia coli have been established. The chorismate analogue lacking the carboxyl group at Ci (5) was not a substrate for chorismate mutase. The methyl ether of chorismate [(f)-6] was a good substrate for chorismate mutase (kCBt/kUnCBt= 2.0 X lo4). The half-lives for Claisen rearrangement ...

(3S,5R)-methyl 3-acetoxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

~%

(3S,5R)-methyl 3-hydroxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

(-)-Methyl (3β,5α)-3-acetoxy-5-hydroxy-1-cyclohexene-1-carboxylate结构式

(-)-Methyl (3β,...

~%

(3S,5R)-methyl 3-hydroxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

methyl (3S,5S)-3,5-di(acetoxy)cyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(3S,5R)-methyl 3-hydroxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

(+)-Methyl (3α,5α)-3,5-dihydroxy-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3α,...

~%

(3S,5R)-methyl 3-hydroxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

methyl (3S,5S)-3,5-dihydroxycyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(3S,5R)-methyl 3-hydroxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

(+)-methyl (1β,2α,6β)-2-hydroxy-7-oxabicyclo[4,1,0]hept-3-ene-4-carboxylate结构式

(+)-methyl (1β,...

~%

(3S,5R)-methyl 3-hydroxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

(-)-Methyl (3β,5α)-3-acetoxy-5-hydroxy-1-cyclohexene-1-carboxylate结构式

(-)-Methyl (3β,...

~%

(-)-Methyl 3-hydroxy-1,5-cyclohexadiene-1-carboxylate结构式

(-)-Methyl 3-hy...

methyl (3S,5S)-3,5-di(acetoxy)cyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(-)-Methyl 3-hydroxy-1,5-cyclohexadiene-1-carboxylate结构式

(-)-Methyl 3-hy...

(3S,5R)-methyl 3-hydroxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

~%

(-)-Methyl 3-hydroxy-1,5-cyclohexadiene-1-carboxylate结构式

(-)-Methyl 3-hy...

(3S,5R)-methyl 3-acetoxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

~%

(-)-Methyl 3-hydroxy-1,5-cyclohexadiene-1-carboxylate结构式

(-)-Methyl 3-hy...

(+)-Methyl (3α,5α)-3,5-dihydroxy-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3α,...

~%

(-)-Methyl 3-hydroxy-1,5-cyclohexadiene-1-carboxylate结构式

(-)-Methyl 3-hy...

methyl (3S,5S)-3,5-dihydroxycyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(-)-Methyl 3-hydroxy-1,5-cyclohexadiene-1-carboxylate结构式

(-)-Methyl 3-hy...

(+)-methyl (1β,2α,6β)-2-hydroxy-7-oxabicyclo[4,1,0]hept-3-ene-4-carboxylate结构式

(+)-methyl (1β,...

~%

(-)-Methyl 3-hydroxy-1,5-cyclohexadiene-1-carboxylate结构式

(-)-Methyl 3-hy...

methyl (3S,5S)-3,5-di(acetoxy)cyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(3S,5R)-methyl 3-acetoxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

(+)-Methyl (3α,5α)-3,5-dihydroxy-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3α,...

~%

(3S,5R)-methyl 3-acetoxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

methyl (3S,5S)-3,5-dihydroxycyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(3S,5R)-methyl 3-acetoxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

(+)-methyl (1β,2α,6β)-2-hydroxy-7-oxabicyclo[4,1,0]hept-3-ene-4-carboxylate结构式

(+)-methyl (1β,...

~%

(3S,5R)-methyl 3-acetoxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

(-)-Methyl (3β,5α)-3-acetoxy-5-hydroxy-1-cyclohexene-1-carboxylate结构式

(-)-Methyl (3β,...

甲基磺酰氯结构式

甲基磺酰氯

~%

(3S,5R)-methyl 3-acetoxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

(-)-Methyl (3β,5α)-3-acetoxy-5-hydroxy-1-cyclohexene-1-carboxylate结构式

(-)-Methyl (3β,...

~%

(+)-Methyl (3β,5β)-3-hydroxy-5-(phenylseleno)-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3β,...

methyl (3S,5S)-3,5-di(acetoxy)cyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(+)-Methyl (3β,5β)-3-hydroxy-5-(phenylseleno)-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3β,...

(3S,5R)-methyl 3-acetoxy-5-((methylsulfonyl)oxy)cyclohex-1-enecarboxylate结构式

(3S,5R)-methyl ...

~%

(+)-Methyl (3β,5β)-3-hydroxy-5-(phenylseleno)-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3β,...

(+)-Methyl (3α,5α)-3,5-dihydroxy-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3α,...

~%

(+)-Methyl (3β,5β)-3-hydroxy-5-(phenylseleno)-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3β,...

methyl (3S,5S)-3,5-dihydroxycyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(+)-Methyl (3β,5β)-3-hydroxy-5-(phenylseleno)-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3β,...

(+)-methyl (1β,2α,6β)-2-hydroxy-7-oxabicyclo[4,1,0]hept-3-ene-4-carboxylate结构式

(+)-methyl (1β,...

~%

(+)-Methyl (3β,5β)-3-hydroxy-5-(phenylseleno)-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3β,...

methyl (3S,5S)-3,5-di(acetoxy)cyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(-)-Methyl (3β,5α)-3-acetoxy-5-hydroxy-1-cyclohexene-1-carboxylate结构式

(-)-Methyl (3β,...

methyl (3S,5S)-3,5-dihydroxycyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(-)-Methyl (3β,5α)-3-acetoxy-5-hydroxy-1-cyclohexene-1-carboxylate结构式

(-)-Methyl (3β,...

(+)-methyl (1β,2α,6β)-2-hydroxy-7-oxabicyclo[4,1,0]hept-3-ene-4-carboxylate结构式

(+)-methyl (1β,...

~%

(-)-Methyl (3β,5α)-3-acetoxy-5-hydroxy-1-cyclohexene-1-carboxylate结构式

(-)-Methyl (3β,...

methyl (3S,5S)-3,5-di(acetoxy)cyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~81%

(+)-Methyl (3α,5α)-3,5-dihydroxy-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3α,...

methyl (3S,5S)-3,5-dihydroxycyclohex-1-enecarboxylate结构式

methyl (3S,5S)-...

~%

(+)-Methyl (3α,5α)-3,5-dihydroxy-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3α,...

(+)-methyl (1β,2α,6β)-2-hydroxy-7-oxabicyclo[4,1,0]hept-3-ene-4-carboxylate结构式

(+)-methyl (1β,...

~%

(+)-Methyl (3α,5α)-3,5-dihydroxy-1-cyclohexene-1-carboxylate结构式

(+)-Methyl (3α,...