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Resolution of trans-1, 2-dihydroxy-1, 2-dihydrobenzene for the preparation of optically pure benzene diol epoxides. Preparation of bromo-and chlorobenzene diol …

MV Ganey, RE Padykula, GA Berchtold…

文献索引:Ganey, Michael V.; Padykula, Robert E.; Berchtold, Glenn A.; Braun, Andrew G. Journal of Organic Chemistry, 1989 ,  vol. 54,  # 12  p. 2787 - 2793

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被引用次数: 33

摘要

(&)-2.8 Bacterial mutagenesis was measured in the Sal-monella typhimurium forward mutation assay of Skopek and co-w~ rkers.~ Benzene was not mutagenic at concentrations up to 1000 lg/mL either in the presence or absence of an exogenous metabolizing system (PMS).'O Dihydrodiol (*)-2 required exogenous metabolism (PMS) for mutagenic activity. Diol epoxide (*)-3 was equally mutagenic in the presence and absence of PMS while diol ...