Stereocontrolled total synthesis of leukotriene B4

…, I Frechard-Ortuno, D Guillerm…

文献索引：Avignon-Tropis; Berjeaud; Pougny; Frechard-Ortuno; Guillerm; Linstrumelle Journal of Organic Chemistry, 1992 ,  vol. 57,  # 2  p. 651 - 654

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被引用次数: 29

摘要

There is a great deal of current interest in hydroxylated eicosatetraenoic acids produced from arachidonic acid by the lipoxygenase pathway.'Leukotriene B4 (LTB4) has received attention due to ita potent chemotactic properties toward macrophages and neutrophiles and ita potential role in Due to the biological importance and the difficulty in isolating LTB4 in quantity from biological material, several groups have developed strategies for synthesis ...