Synthesis of L-Leucyl-L-alanyl-L-valyl-L-glutamic Acid and Intermediate Peptides1

WH McGREGOR, FH CARPENTER

文献索引：McGregor,W.H.; Carpenter,F.H. Journal of Organic Chemistry, 1961 ,  vol. 26, p. 1849 - 1854            

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被引用次数: 11

摘要

In the course of this work several observations of general interest in peptide synthesis were made. One of these was the superiority of the benzyl over the methyl ester for use in the preparation of the hydrazide of p-nitrobenzyloxycarbonyl-cleucyl-> alanyl-cvaline. The hydrazide of this tripeptide was prepared by treatment of the benzyl ester with hydrazine at 37'for several days. Under similar or even more vigorous conditions, the methyl ester ...