A new stereoselective synthesis of (20 R)-and (20 S)-steroidal side chains

T Ibuka, T Taga, S Nishii, Y Yamamoto

文献索引：Ibuka, Toshiro; Taga, Tooru; Nishii, Shinji; Yamamoto, Yoshinori Journal of the Chemical Society, Chemical Communications, 1988 ,  # 5  p. 342 - 344

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被引用次数: 6

摘要

Reaction of (E)-ethyl 3β-t-butyldimethylsiloxypregna-5, 17-dien-21-oate with lithium di- isopropylamide followed by alkyl halides results in the predominant formation of (20S)- alkylation products in> 88% isolated yields; a synthetic application to both (20R)-and (20S)- steroidal side chains is also described.