Total synthesis of (+)-latrunculin B

R Zibuck, NJ Liverton, AB Smith

文献索引：Zibuck, Regina; Liverton, Nigel J.; Smith, Amos B. Journal of the American Chemical Society, 1986 ,  vol. 108,  # 9  p. 2451 - 2453

全文：HTML全文

被引用次数: 45

摘要

Aldehyde 9 was prepared in four steps beginning with the Baeyer-Villager oxidation of 2- allylcyclopentanone (12). 14 Alkylation provided 141Za as a 1: l mixture of lactones, which in turn was protected as the ortho ester, 12a employing (+)-(R, R)-2, 3-butanediol. 15 The latter operation served not only to equilibrate the mixture to a 6: 1 trans/& mixture (15a, b/15c, d)