New dibenzothiadiazepine derivatives with antidepressant activities

D Giannotti, G Viti, P Sbraci, V Pestellini…

文献索引：Giannotti; Viti; Sbraci; Pestellini; Volterra; Borsini; Lecci; Meli; Dapporto; Paoli Journal of Medicinal Chemistry, 1991 ,  vol. 34,  # 4  p. 1356 - 1362

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被引用次数: 33

摘要

A new series of 11-[(aminoalkyl) carbonyl] derivatives of 6, 11-dihydrodibenzo [c, fl [1, 2, 5] thiadiazepine 5, 5-dioxide (10-39) were synthesized and evaluated for potential antidepressant activity in the apomorphine-induced hypothermia (Apo 16) test. Effecta on reserpine-induced hypothermia and toxicity for the most potent antagonists of Apo 16 hypothermia were also studied. Structure-activity relationships are reported. ...