Organic letters

Soluble α-amino acid salts in acetonitrile: practical technology for the production of some dipeptides

C Palomo, AL Palomo, F Palomo, A Mielgo

文献索引：Palomo, Claudio; Palomo, Antonio L; Palomo, Francisco; Mielgo, Antonia Organic letters, 2002 , vol. 4, # 23 p. 4005 - 4008

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被引用次数: 20

摘要

α-Amino acids are soluble in acetonitrile when treated with phosphazene bases. As a result, the protection/deprotection events that are usually required for peptide coupling reactions can be minimized. This is illustrated in the synthesis of the important angiotensin-converting enzyme (ACE) inhibitor enalapril.