Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase

G Ma, M Zancanella, Y Oyola, RD Richardson…

文献索引：Organic Letters, , vol. 8, # 20 p. 4497 - 4500

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被引用次数: 44

摘要

... Volume: Page: ... Organic Letters. ... The synthesis of (−)-tetrahydrolipstatin began with a TMAL reaction between known aldehyde 4 16 and thiopyridyl ketene acetal 5 7 which delivered the desired β-lactone as an 8:1 mixture of anti/syn diastereomers with complete ...