Improved process for the preparation of montelukast: Development of an efficient synthesis, identification of critical impurities and degradants

…, J Jirman, O Boušková, P Gibala…

文献索引：Dufresne, Claude; Gallant, Michel; Gareau, Yves; Ruel, Rejean; Trimble, Laird; Labelle, Marc Journal of Organic Chemistry, 1996 ,  vol. 61,  # 24  p. 8518 - 8525

全文：HTML全文

被引用次数: 15

摘要

... Select a Journal or Book ... a salt of montelukast 1 with an alkali metal and several undesired impurities dissolved together in organic solvents used. ... well-crystallizing salts with amines, followed by recrystallization of these salts with simultaneous removal of chemical impurities ...