Development of a bulk enabling route to Maraviroc (UK-427,857), a CCR-5 receptor antagonist

SJ Haycock-Lewandowski, A Wilder…

文献索引：Organic Process Research and Development, , vol. 12, # 6 p. 1094 - 1103

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被引用次数: 48

摘要

... Organic Process Research & Development. ... figure Scheme 1. Retrosynthetic analysis of Maraviroc (UK-427,857). Initial efforts were focused on development of the synthesis of the ... of exo-amine 7 was performed on 20 g scale in batch mode to support process research activities. ...