Mild and Expedient Asymmetric Reductions of α, β-Unsaturated Alkenyl and Alkynyl Ketones by TarB-NO2 and Mechanistic Investigations of Ketone Reduction
…, C DeLieto, WJ McDonald, D Haddenham…
文献索引：Eagon, Scott; Delieto, Cassandra; McDonald, William J.; Haddenham, Dustin; Saavedra, Jaime; Kim, Jinsoo; Singaram, Bakthan Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7717 - 7725
A facile and mild reduction procedure is reported for the preparation of chiral allylic and propargyl alcohols in high enantiomeric purity. Under optimized conditions, alkynyl and alkenyl ketones were reduced by TarB-NO2 and NaBH4 at 25° C in 1 h to produce chiral propargyl and allylic alcohols with enantiomeric excesses and yields up to 99%. In the case of α, β-unsaturated alkenyl ketones, α-substituted cycloalkenones were reduced with up to ...
