Properties and tissue distribution of a novel aldo–keto reductase encoding in a rat gene (Akr1b10)

…, S Ohno, Y Kitade, K Tajima, O El-Kabbani…

文献索引：Endo, Satoshi; Matsunaga, Toshiyuki; Kuragano, Tsukasa; Ohno, Satoshi; Kitade, Yukio; Tajima, Kazuo; El-Kabbani, Ossama; Hara, Akira Archives of Biochemistry and Biophysics, 2010 , vol. 503, # 2 p. 230 - 237

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被引用次数: 20

摘要

A recent rat genomic sequencing predicts a gene Akr1b10 that encodes a protein with 83% sequence similarity to human aldo–keto reductase (AKR) 1B10. In this study, we isolated the cDNA for the rat AKR1B10 (R1B10) from rat brain, and examined the enzymatic properties of the recombinant protein. R1B10 utilized NADPH as the preferable coenzyme, and reduced various aldehydes (including cytotoxic 4-hydroxy-2-hexenal and 4-hydroxy-and 4-oxo-2- ...