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Some structural changes on triazolyl-benzotriazoles and triazolyl-benzimidazolones as potential potassium channel activators. III

…, V Calderone, I Giorgi, O Livi, V Scartoni, B Baragatti…

文献索引：Biagi, Giuliana; Calderone, Vincenzo; Giorgi, Irene; Livi, Oreste; Scartoni, Valerio; Baragatti, Barbara; Martinotti, Enrica Farmaco, 2001 , vol. 56, # 11 p. 841 - 849

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被引用次数: 35

摘要

This paper reports the synthesis and pharmacological evaluation of some compounds, obtained by structural modifications of 1, 2, 3-triazolyl-benzotriazoles and 1, 2, 3-triazolyl- benzimidazolones, which had shown activity as potential activators of the big-conductance calcium-activated potassium channels (BKCa). Changes have concerned the introduction of a hinderer substituent in the 5-position of the benzimidazolone (4a, b) and benzotriazole ( ...