Tetrahedron letters

Synthesis of novel dimeric cationic lipids based on an aromatic backbone between the hydrocarbon chains and headgroup

B Paul, A Bajaj, SS Indi, S Bhattacharya

文献索引：Paul, Bishwajit; Bajaj, Avinash; Indi; Bhattacharya, Santanu Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8401 - 8405

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被引用次数: 12

摘要

Seven dimeric cationic lipids possessing an aromatic anchor between the hydrocarbon chains and cationic headgroup have been synthesized. The spacers in these lipids vary in length, hydrophobicity and flexibility. The synthesis, membrane-forming properties and complexation with plasmid DNA (lipoplex formation) are briefly described.