Synthetic Communications

Synthesis of 2??Substituted 4, 5??Diphenyloxazoles under Solvent??Free Microwave Irradiation Conditions

JC Lee, JW Seo, JW Baek

文献索引：Lee, Jong Chan; Seo, Jang-Woo; Baek, Jong Wook Synthetic Communications, 2007 , vol. 37, # 13 p. 2159 - 2162

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被引用次数: 13

摘要

View all references Therefore, it is highly desirable to develop a new method for the synthesis of oxazoles starting from ketones using a reagent combination of HTIB and nitriles. Herein, we report a novel and facile method for the synthesis of 2??substituted 4,5??diphenyl oxazoles from the reaction of deoxybenzoin with HTIB and various nitriles under microwave irradiation conditions. Thus, sequential treatment of deoxybenzoin with HTIB (1.2 equiv.) and nitriles ( ...