Substituted benz [a] acridines and benz [c] acridines as mammalian topoisomerase poisons

D Makhey, C Yu, A Liu, LF Liu, EJ LaVoie

文献索引：Makhey, Darshan; Yu, Chiang; Liu, Angela; Liu, Leroy F.; Lavoie, Edmond J. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 1171 - 1182

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被引用次数: 37

摘要

Coralyne and several other synthetic benzo [a, g] quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the presence of a positively charged iminium group, which has been postulated to be associated with their pharmacological properties. The objective of the present study was to devise stable noncharged bioisosteres of these compounds. ...