Tetrahedron

New approaches toward the synthesis of (D-homo) steroid skeletons using Mukaiyama reactions

…, A Baranovsky, BJM Jansen, MA Posthumus…

文献索引：Saraber, Florence C. E.; Baranovsky, Alexander; Jansen, Ben J. M.; Posthumus, Maarten A.; De Groot, Aede Tetrahedron, 2006 , vol. 62, # 8 p. 1726 - 1742

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被引用次数: 19

摘要

New, short, and flexible procedures have been developed for syntheses of steroid and D- homo steroid skeletons. A Mukaiyama reaction between the silyl enol ether of 6- methoxytetralone and 2-methyl-2-cyclopentenone or carvone, with transfer of the silyl group to the receiving enone, gave a second silyl enol ether. Addition of a carbocation, generated under Lewis acid conditions from 3-methoxy-2-butenol, 3-ethoxy-3-phenyl-2-propenol or 3 ...