Multicomponent heterocyclization of carboxamides with H2S and CH2O

…, RR Khairullina, GR Nadyrgulova…

文献索引：Akhmetova; Khairullina; Nadyrgulova; Kunakova; Dzhemilev Russian Journal of Organic Chemistry, 2008 , vol. 44, # 2 p. 190 - 196

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被引用次数: 11

摘要

Abstract Multicomponent heterocyclization of aliphatic amides with H 2 S and CH 2 O (1: 3: 2) in water-organic solvent mixture in the presence of BuONa led to the formation of 1, 3, 5- dithiazinane in high yield (30–95%) and with high selectivity (100%). Under these conditions benzamide gave 3, 5-dibenzoyl-1, 3, 5-thiadiazinane in 74% yield, whereas due to ortho- effect the acetylsalicylamide with H 2 S and CH 2 O in a system BuOH-H 2 O without ...