Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors

F Julémont, X De Leval, C Michaux…

文献索引：Julemont, Fabien; De Leval, Xavier; Michaux, Catherine; Damas, Jacques; Charlier, Caroline; Durant, Francois; Pirotte, Bernard; Dogne, Jean-Michel Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5182 - 5185

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被引用次数: 40

摘要

In this study, we report the synthesis and pharmacological evaluation of original pyridinic sulfonamides related to nimesulide, a cyclooxygenase-2 (COX-2) preferential inhibitor widely used as an anti-inflammatory agent. These original pyridinic derivatives were synthesized in three steps starting from the condensation of 3-bromo-4-nitropyridine N-oxide with appropriately substituted phenols, thiophenols, or anilines followed by a reduction of ...