Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription …

JJ Heynekamp, WM Weber, LA Hunsaker…

文献索引：Heynekamp, Justin J.; Weber, Waylon M.; Hunsaker, Lucy A.; Gonzales, Amanda M.; Orlando, Robert A.; Deck, Lorraine M.; Vander Jagt, David L. Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7182 - 7189

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被引用次数: 151

摘要

The transcription factor nuclear factor kappaB (NF-κB), which regulates expression of numerous antiinflammatory genes as well as genes that promote development of the prosurvival, antiapoptotic state is up-regulated in many cancer cells. The natural product resveratrol, a polyphenolic trans-stilbene, has numerous biological activities and is a known inhibitor of activation of NF-κB, which may account for some of its biological activities. ...