Tetrahedron Letters

Tandem reversible addition–intramolecular lactonization for the synthesis of 3-functionalized phthalides

M Sakulsombat, M Angelin, O Ramström

文献索引：Sakulsombat, Morakot; Angelin, Marcus; Ramstroem, Olof Tetrahedron Letters, 2010 , vol. 51, # 1 p. 75 - 78

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被引用次数: 13

摘要

A new tandem process based on reversible nucleophilic addition and intramolecular lactonization of methyl 2-formylbenzoate leads to the efficient synthesis of 3-functionalized phthalides, which are important precursors for the synthesis of quinone skeletons via Hauser– Kraus annulation. The reactions are successfully carried out under mild conditions in single operations.