Synthesis of [14C]??and [13C6]??labeled tipranavir and its potential hydroxyl metabolite and the glucuronide conjugate

…, D Krishnamurthy, CH Senanayake

文献索引：Latli, Bachir; Hrapchak, Matt; Easter, John A.; Stolle, Wayne T.; Grozinger, Karl; Krishnamurthy, Dhileepkumar; Senanayake, Chris H. Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 8 p. 314 - 320

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被引用次数: 5

摘要

Abstract Tipranavir or Aptivus® is a non-peptidic protease inhibitor approved for the combination treatment with ritonavir of HIV infection. Tipranavir labeled with radioactive and stable isotopes of carbon was required for drug metabolism (excretion, distribution, and absorption) studies and to develop bioanalytical methods needed for the support of clinical studies.[7-14 C]-Benzoic acid and uniformly labeled benzoic acid (ring-13 C 6 99 at% 13 ...