Modification of the side chain of micromolide, an anti-tuberculosis natural product

…, R He, B Wan, Y Wang, GF Pauli, SG Franzblau…

文献索引：Yuan, Hai; He, Rong; Wan, Baojie; Wang, Yuehong; Pauli, Guido F.; Franzblau, Scott G.; Kozikowski, Alan P. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5311 - 5315

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被引用次数: 10

摘要

This paper describes a series of modifications of the side chain of micromolide, an anti- tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.