Uncatalysed preparation of α-amino phosphonates under solvent free conditions

M Zahouily, A Elmakssoudi, A Mezdar…

文献索引：Zahouily, Mohamed; Elmakssoudi, Abdelhakim; Mezdar, Abdessamad; Rayadh, Ahmed; Sebti, Said Journal of Chemical Research, 2005 , # 5 p. 324 - 327

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被引用次数: 12

摘要

A simple, efficient and environmentally friendly procedure has been developed for the three component coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphites to produce α-amino phosphonates. The α-amino phosphonates are synthesised in high yields (74-97%) in a few minutes (1-3 min) by microwave irradiation under solvent- free conditions, avoiding the use of any catalyst.