Tetrahedron letters

Palladium-catalyzed cyclization of alkenyl and aryl halides containing α, β-Unsaturated carbonyl groups via intramolecular carbopalladation

B O'Connor, Y Zhang, E Negishi, FT Luo, JW Cheng

文献索引：O'Connor, Brian; Zhang, Yantao; Negishi, Ei-ichi Tetrahedron Letters, 1988 , vol. 29, # 32 p. 3903 - 3906

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被引用次数: 35

摘要

Abstract Treatment of alkenyl and aryl iodides and bromides containing an appropriate α, β- unsaturated carbonyl group with a catalytic amount (3–5 mol%) of either a Pd (O) or a Pd (II) complex, eg, Pd (PPh 3) 4, and a base, eg, NEt 3, can induce highly regioselective cyclization via intramolecular carbopalladation; formation of exocyclic alkenes can also be highly stereoselective.